Intravitreal Systems For Targeted Drug Delivery To The Posterior Eye Segment: A Systematic Review

review of intravitreal implants for extended drug delivery to the posterior segment of the eye

intravitreal injection is the most common approach for drug delivery to the posterior segment in humans. however, following the injection, drugs are rapidly eliminated from the vitreous, with half-lives up to a few days. depending on the rate of clearance from the vitreous, large boluses and frequent administrations may be required to ensure therapeutic levels over an extended period of time. m...

Drug delivery for posterior segment eye disease.

In recent years, significant advances have been made in optimizing the delivery of drugs to target tissues within the eye and in maintaining effective drug doses within those tissues. Most pharmacologic management of ocular disease, however, continues to use the topical application of solutions to the surface of the eye as drops. Factors that can limit the usefulness of topical drug application...

Targeted administration into the suprachoroidal space using a microneedle for drug delivery to the posterior segment of the eye.

PURPOSE This study seeks to determine the intraocular pharmacokinetics of molecules and particles injected into the suprachoroidal space of the rabbit eye in vivo using a hollow microneedle. METHODS Suprachoroidal injections of fluorescein and fluorescently tagged dextrans (40 and 250 kDa), bevacizumab, and polymeric particles (20 nm to 10 μm in diameter) were performed using microneedles in ...

Delivery of therapeutics to posterior eye segment: cell-encapsulating systems

Thermoresponsive hydrogels as a new ocular drug delivery platform to the posterior segment of the eye.

PURPOSE To characterize thermoresponsive hydrogels (liquids at room temperature, gels at body temperature) as a novel drug delivery platform to the posterior segment. METHODS Thermoresponsive hydrogels were synthesized using poly(N-isopropylacrylamide) (PNIPAAm), cross-linked with poly(ethylene glycol) diacrylate (PEG-DA). Proteins were then encapsulated into the hydrogels, including bovine s...